| 1. Ubiquitin–proteasome system: function and regulatory mechanisms | Elucidating how the ubiquitin–proteasome system is regulated at multiple levels to control selective protein turnover in cells. |
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| 2. Autophagy and related degradation pathways | Exploring autophagic mechanisms and their crosstalk with other proteolytic systems in maintaining cellular homeostasis. |
| 3. Structure and dynamics of degradation machinery | Revealing the architecture and conformational dynamics of degradation complexes through structural and biophysical studies. |
| 4. Degrons and substrate recognition | Defining how degron motifs are identified and recognized to ensure substrate specificity in protein degradation. |
| 5. Targeted protein and organelle degradation | Highlighting selective degradation strategies, with an emphasis on novel methodological advances and their potential applications. |
| 6. Proteome remodeling | Examining large-scale proteome reconfiguration during development, stress responses, and disease progression. |
| 7. Protein quality control | Focusing on cellular mechanisms that monitor and eliminate misfolded or damaged proteins to sustain proteostasis. |
